pentobarbital will lessen the extent or effect of mestranol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
C: Use with warning if Added benefits outweigh hazards. Animal scientific studies demonstrate threat and human reports not accessible or neither animal nor human research carried out.
Extended or repeated publicity may well cause unfavorable effects on fetal or young youngsters’s brain advancement
pentobarbital will reduce the extent or impact of abiraterone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
fentanyl transdermal and pentobarbital both raise sedation. Steer clear of or Use Alternate Drug. Restrict use to clients for whom alternate treatment method options are inadequate
pentobarbital will lessen the extent or impact of bosentan by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unknown.
pentobarbital and olopatadine intranasal both maximize sedation. Prevent or Use Alternate Drug. Coadministration improves chance of CNS depression, which may lead to additive impairment of psychomotor effectiveness and result in daytime impairment.
pentobarbital will minimize the extent or influence of apremilast by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration with sturdy CYP inducers ends in a major reduce of systemic publicity of apremilast, which can cause loss of efficacy
pentobarbital will lower the level or effect of levonorgestrel oral/ethinylestradiol/ferrous bisglycinate by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Carefully. The efficacy of hormonal contraceptives might be minimized.
pentobarbital will lessen the level or effect of buprenorphine subdermal implant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Closely. Check people now on buprenorphine subdermal implant who demand freshly-initiated therapy with CYP3A4 inducer for signals here and signs and symptoms of withdrawal.
pentobarbital will minimize the extent or influence of levamlodipine by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will decrease the level or influence of ripretinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will minimize the extent or impact of conjugated estrogens, vaginal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
pentobarbital raises toxicity of methoxyflurane by expanding metabolism. Contraindicated. Elevated metabolism of methoxyflurane to nephrotoxic compounds.